Proviron Schering 25 mg is the Schering brand for the oral androgen mesterolone (1 methyl-dihydrotestosterone). As with DHT, this steroid’s activity is that of a strong androgen that does not aromatize to estrogen. In clinical situations, Proviron Schering 25 mg is normally used to treat various types of sexual dysfunction, which is often the result of a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotence and is sometimes used to increase sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen replacement agent used to compensate for the lack of the natural male androgen.
Although this steroid is highly androgenic, its anabolic effect is considered too weak for muscle building. This is due to the fact that Proviron® is quickly reduced to inactive metabolites in muscle tissue, a feature that also characterizes dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue and thereby reduce the gains of other more potent muscle building steroids should also not be taken seriously. Due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron Schering 25mg can actually work to enhance the activity of other steroids by moving a higher percentage to a free, unbound state. Among athletes, Proviron® is primarily used as an antiestrogen. It is believed to act as an antiaromatase in the body, which prevents or slows down the conversion of steroids to estrogen. The result is somewhat comparable to Arimidex® (although less profound), the drug that works to prevent estrogen build-up in the body. This is in contrast to Nolvadex®, which only blocks estrogen’s ability to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred because it is a more direct and effective way of dealing with the problem of estrogenic side effects. A related disadvantage of Nolvadex® is that if discontinued prematurely, a rebound effect may occur as high serum estrogen levels are again free to act. This can of course mean a rapid onset of side effects such as gynecomastia and water retention. Most athletes actually prefer to use both Proviron Schering 25 mg and Nolvadex®, especially during highly estrogenic cycles. When each item attacks estrogen from a different angle, side effects are often greatly minimized.
The anti-estrogenic properties of Proviron Schering 25 mg are not unique to this compound. A number of steroids have actually shown similar activity. For example, Dihydrotestosterone and Masteron (2-methyl-dihydrotestosterone) have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization appears to be the liver). The antiestrogenic effect of all these compounds is probably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet unable to change it,
This drug is also favored by many during competition preparations when a lower estrogen / high androgen level is particularly desired. This is particularly beneficial when anabolics such as Winstrol®, Oxandrolone, and Primobolan® are used alone because the androgenic content of these drugs is relatively low. Proviron Schering 25 mg can supplement a well-known androgen and cause an increase in muscle hardness and density. Women in particular will find a single 25mg tablet will alter the androgen/estrogen ratio effectively and can have a major impact on the body. However, because this is such a strong androgen, extreme caution should be taken when administering. Higher doses clearly have the potential to cause virilization symptoms quite easily. For this reason, women rarely take more than one tablet per day and limit the duration of intake to no longer than four or five weeks. A tablet used in conjunction with 10 or 20 mg of Nolvadex® can be even more effective for muscle hardening, creating an environment where the body is much more likely to burn off extra body fat (especially in female problem areas such as hips and thighs).
The typical dose for men is one to four 25 mg tablets per day. This is a sufficient amount to prevent gynecomastia, the drug that is often used throughout a strong cycle. As mentioned earlier, it is often combined with Nolvadex® (tamoxifen citrate) or Clomid® (clomiphene citrate) when highly estrogenic steroids are taken (Dianabol, testosterone, etc.). Administering 50 mg Proviron Schering 25 mg and 20 mg Nolvadex® daily has been shown to be extremely effective in such cases, and it is quite uncommon for higher doses to be required. And just as we discussed for women, the androgenic nature of this compound is very welcome during competition preparation. Here too, Proviron Schering 25 mg should noticeably favor muscle hardness and density, while increasing the tendency to burn off a greater amount of body fat. Proviron® is usually well tolerated and side effects (men) are rare with doses below 100 mg per day. Above this one can develop an excessively high androgen level and run into some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth, and worsening of male pattern baldness, and may occur even with moderate dose use. With the strong effect DHT has on the reproductive system, androgenic actions can also include an extreme increase in male libido. And as discussed earlier, women should be careful around Proviron Schering 25 mg. It is an androgen, and as such has the potential to produce virilization symptoms quite easily. This naturally includes a deepening of the voice, menstrual irregularities, changes in the texture of the skin and clitoral enlargement.
Proviron Schering 25 mg is also not a c17 alpha alkylated compound, a change commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Proviron Schering 25 mg removes the noticeable risk of hepatotoxicity that we normally associate with oral dosing. We therefore consider this to be a ”safe” oral, the user need not worry about serious complications when using. This steroid actually uses the same 1-methylation that we see present on Primobolan® (methenolone), another well-tolerated orally active compound. Alkylation at the one position also slows the metabolism of the steroid during the first pass, although it is much less profound than 17 alpha alkylation. Likewise is Proviron Schering 25 mg and Primobolan® sufficiently resistant to degradation to allow therapeutically beneficial blood levels, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.
The popularity of Proviron Schering 25 mg among bodybuilders has increased in recent years. Many experienced bodybuilders have actually come to swear by it and integrate it effectively into the most markedly estrogenic cycles. Due to high demand, Proviron® is now very easy to obtain on the black market. Most versions will be manufactured by Schering and should cost around $1-$2 per 25mg tab. In many cases this item is obtained via mail order, and here can be sold for less than 0.50 per tab. This medicine is packaged in both pull-through strips and small glass bottles, so don’t let this worry you. There is currently no need to worry about the authenticity of this drug, as counterfeits are not known to exist. If money and availability do not prevent it, Arimidex® is actually a much better choice than Proviron Schering 25 mg. This drug was specifically designed as an anti-aromatase and works far more effectively than anything else we have available. However, since this item is extremely expensive, Nolvadex® and Proviron® will undoubtedly remain the “standard” anti-estrogen regimen among athletes.